• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to novel iminothiazolidine derivatives of the formula (I), <IMAGE> (I) wherein R1 and R3 represent, independently from each other, hydrogen or lower alkyl group, R3 is nitro or amino group, R stands for halo, lower alkyl, haloalkyl, nitro, amino, hydroxy, lower alkoxy, carboxy or lower alkoxycarbonyl group, and n is 0, 1 or 2, and pharmaceutically acceptable acid addition salts thereof. The iminothiazolidine derivatives of the formula (I) possess valuable antidepressant, antiparkinsonic, antiepileptic and spasmolytic activities.
    公开号:SU1549480A3
    申请号:SU864027048
    申请日:1986-03-05
    公开日:1990-03-07
    发明作者:Лемперт Карой；Хорниак Дьюла；Барта Ференц；Долешалл Габор；Феттер Йожеф；Ньитраи Йожеф；Шимиг Дьюла；Зауер Карой；Хусти Петер；Феллер Антал；Петец Луиза；Сирт Енике；Грашшер Каталин；Береньи Эдит；Орр Жужанна；Пьецка Этелка
    申请人:Эгиш Дьедьсердьяр (Инопредприятие)；
    IPC主号:
    专利说明:

    The invention relates to a method for the preparation of new biologically active chemical compounds, specifically to a method for the preparation of new derivatives of iminothiaeolidine or their hydrochlorides, possessing antidepressant, antiepileptic, antiparkinsonian and analgesic activity, and can be used in medicine.
    The aim of the invention is to obtain new derivatives of the iminoheteroazolidine series, possessing a new look for this range of compounds of biological activity.
    Example 1. Preparation of 2-imino-3- (2-nitrophenyl) thiazolidine hydrochloride.
    To a solution of 4.0 g (18 mol) of 2-nitro-C- (2-thiocyanatoethyl) -aniline in 50 ml of ethanol, hydrogen chloride is passed through boiling for 30 minutes. After cooling, the precipitated crystals are filtered and washed with ether. 3.9 of the title compound is obtained as a yellow crystalline powder. Yield 83%. M.p. 286 C (decomposition, ethanol-ether).
    cl
    50 50

    00
    with
    Calculated% U C1 13.66; N 16.17; S 12.34.
    C9H40 ClN, OtS
    Found,%: Cl 13.54; N 16.23;
    S 12.04.
    The base is recovered as follows.
    1.3 g (5 mol) of the indicated hydrochloride is dissolved in 30 ml of water, after which the solution is alkalinized to pH 9 with 40% aqueous sodium hydroxide solution. The crystals separated out were filtered, washed with water, and crystallized from a mixture of ethyl acetate and petroleum ether. 1.0 g of 2-imino-3- (2-nitrophenyl) -thiazolidine is obtained as a yellow crystalline powder. Yield 90%, mp. .
    PRI mme R 2. Obtaining 2-imino-3- (4-methyl-2-nitrophenyl) -thiazolidine chloride.
    2.0 g (8.4 mol) of 4-methyl-2-nitro-L- (2-thiocyanatoethyl) -aniline in 50 ml of ethanol is boiled for 1 hour while passing gaseous hydrogen chloride. The initially heterogeneous reaction mixture becomes homogeneous by the end of the transformation. The solution is evaporated to about half the original volume and cooled. The crystals separated out are filtered, washed with a small amount of ethanol and ether. 1.8 g of the title compound are obtained, yield 78%. The yellow crystalline powder melts at 287-289 ° C.

    The base is separated out.
    zom.
    1 g of this hydrochloride was thoroughly shaken with a mixture of 20 ml of a saturated solution of potassium carbonate and 25 ml of chloroform. The phases are separated and the aqueous phase is extracted three times with 0 ml of chloroform. The combined organic phases are dried over magnesium sulphate and concentrated. 0.78 g of 2-amino-3 (4-methyl-2-nitrophenyl) -thiazolidine is obtained. Yield 90%, mp. 132-134 ° C (ether-petroleum ether), yellow crystalline powder.
    Calculated,%: C 50.62; H 4.67; N 17.71; S 13.51.
    C, pH44N304S
    Found,%: C 50.52; H 4.59; N 17.09, S 13.69.

    five
    0
    50
    five
    0
    EXAMPLE 3. Preparation of 2-imino-3- (4-methoxycarbonyl-2-nitrophenyl) -thiazolidine hydrochloride.
    - In a mixture of 0.5 g (1.8 mmol) of methyl 3- -nitro-4-CM (2-thiocyanatoethyl) amino benzoate and 10 ml of anhydrous methanol, hydrogen chloride gas is passed in at boiling for 1 hour. The solution is evaporated to about one-third of the original volume, and by the addition of ether, it causes crystallization. After cooling, the separated crystals are filtered and washed with ether. 0.4 g of the title compound is obtained, yield 71%, m.p. 242 ° C (decomposition, methanol-ether).
    The base is inserted as follows.
    1 g of this hydrochloride was thoroughly shaken with a mixture of 20 ml of saturated aqueous sodium carbonate and 30 ml of dichloromethane. The phases are separated from each other and the aqueous phase is fixed twice more in 10 ml of dichloromethane. The combined organic phases are dried and evaporated. 0.8 g of 2-imino-3- (4-methoxycarbonyl-2-nitrophenyl) -thiazolidine is obtained. You are 1 move 80%, so pl. 156 ° C. BUT
    Thus, obtained again based on the melting point, IR spectrum and thin layer chromatography is toluene: ethyl acetate 1: 1; RJ: 0.25.
    EXAMPLE 4. Preparation of 2-imino-3- (2-nitro-4-trifluoromethylphenyl) -thiazidoidine hydrochloride.
    To a solution of 5 g (17 mmol) of 2-nitro-4-trifluoromethyl-III- (2-thiocyanatoethyl) -aniline in 30 ml of ethanol, dry hydrogen chloride gas is passed through boiling for 1 h. At the end of the reaction, precipitation of crystals begins. After cooling, the precipitated crystals are filtered and washed with ether. 4.5 g of the title compound are obtained. Yield 81%. A pale yellow crystalline powder melts at 295 ° C (decomposition, ethanol).
    Calculated,%: C1 10.83 ;, N, 12.82; S 9.78.
    С „0 Н9 C1F3 N, Oe S
    Found,%: C1 10.93; N 12.78; S 9.57.
    PRI me R CH5. Preparation of 2-imino-3-C4-methoxy-2-nitrophenyl) thiazolidine hydrochloride.
    5-15494806
    In suspension 2.5 g (10 mol) 4-meni. 83% yield, m.p. 279-281 С (concurrent si-2-HHTpo-N- (2-thiocyanatoethyl) - position: methanol-ether).
    aniline in 60 ml of anhydrous ethanol at a boil for 1 h pass dry gaseous hydrogen chloride. After cooling, the separated crystals are filtered and washed with ether. 2.1 g of the title compound are obtained, yield 73%. A yellowish white crystalline powder melts at 288-290 ° C (dimethylformamide ester).
    Calculated,%: C1 12.25; N 14.50; S 11.06.
    C "in H, e.ClNsOsS
    Found,%: C1 12.43; N 14.23; S 10.91.
    The base was isolated from this salt with a 40% aqueous solution of sodium hydroxide, m.p. 108-110 ° C (ethyl acetate-petroleum ether). Crystal powder. Red.
    PRI me R 6. Preparation of 2-imino-3- (4-chloro-2-nitrophenyl) -thiazolidine hydrochloride.
    To a suspension of 5.15 g (20 mmol) of 4-chloro-2-nitro-L- (2-thiocyanatoethyl) - aniline in 50 ml of anhydrous ethanol at boiling for 1 h, dry hydrogen gas is passed through. The color of the crystalline mass changes from orange-yellow to light yellow. After cooling, the separated crystals are filtered and washed with ether. 5.5 g of the title compound are obtained, yield 93%, m.p. 295-296 eС (decomposition, ethanol). Calculated,%: C1 24.04; N 14.24; S 10.87.
    C9H9S1GY4Og.5
    Found,%: C1 24.08; N 13.88; S 10.61.
    Example 7. Obtaining 2-imino-3- (5-chloro-2-nitrophenyl) -thiazolidine hydrochloride.
    To a suspension of 11.5 g (45 mol) of 5-chloro-2-nitro-N- (2-thiocyanatoethyl) - aniline in 100 ml of anhydrous ethanol, dry hydrogen chloride gas is passed in at boiling for 30 minutes. The solution is evaporated under reduced pressure to half the original volume. After cooling, the separated crystals are filtered and washed with ether. 11 g of the indicated compound is obtained in the form of a pale yellow crystalline powder.
    0
    0
    five
    Calculated,%: C1 24.04; N 14.24; S 10.87.
    CgH9ClzN3OaS
    Found,%: C1 23.92; N 14.43, S 11.20.
    EXAMPLE 8 Preparation of 2-imino-5-methyl-3- (4-chloro-2-nitrophenyl) -thiazolidine hydrochloride.
    To a suspension of 12 g (44 mmol) of 4-chloro-2-nitro-I- (2-methyl-2-thiocyanato-ethyl) -aniline in 150 ml of anhydrous ethanol, gaseous hydrogen chloride is passed in under boiling for 2 hours. After 30 minutes a homogeneous solution is formed and the precipitation of crystals begins. After cooling, the separated crystals are filtered and washed successively with ethanol and ether. 11.5 g of the title compound are obtained in the form of a light yellow crystalline powder. Yield 85%, 5 m.p. 281-283 ° C.
    Calculated,%: C 38.96; H 3.59; N 10.40.
    Sio N. m Cl2NjO t
    Found,%: C 38.75; H 3.30, 0 N 10.72.
    PRI me R 9. Preparation of 2,4,6-trinitro-H- (2-thiocyanatoethyl) aniline.
    a) 6 g (22 mmol) of 1U- (2-hydroxyethyl) - 2,4,6-trinitroaniline are dissolved in 18 ml of pyridine, then 2.4 ml (31 mmol) of methanesulfonic acid chloride are added dropwise with ice cooling. The reaction mixture is stirred for 2 hours and poured into 100 ml of ice sheet. Isolated crystals are filtered, washed with water. 5.5 g of N- (2-methyloxy-5 ethyl) -2,4,6-trinitroaniline are obtained in the form of orange-yellow crystals; yield 71%, mp. 121-123 ° C (ethyl acetate).
    Calculated,%: C 30.86; H 2.88; N 16.00; S 9.15.
    C9H, 0N409S
    Found,%: C 30.90; H 2.71; H 2.71, N 15.92; S 9.21.
    b) A mixture of 5 g (14 mmol) P {2-methyl-hydroxyethyl) -2,4,6-trinitroaniline, 4 g (40 mmol) of potassium rhodanide and 50 ml of 5 anhydrous dimethylformamide is stirred for 1.5 h at. The reaction mixture was poured into ice water, the separated crystals were filtered and washed thoroughly with water. Semi5
    0
    0
    3.8 g of the title compound are indicated as orange-red crystals. Yield 87%, mp. 124-126 ° C (ethyl acetate)
    Calculated,%: C 34.51; H 2.25; N 22.36; S 10.24. C9H7N506S
    Found,%: C 34.34; H 2.50). N 21.94; S 21.94.
    The proposed compounds have valuable antidepressant, antiparkinicheskih, antiepileptic and antispasmodic properties that are associated with insufficient (moderate) analgesic action.
    The activity of the proposed compounds is proved by the following test tests. Test methods.
    Acute toxicity on myta, Toxicity is determined on females and male white mice (of the CFLP genus, body weight 18-22 g). For each dose, 6 animals are used. Test compounds are administered orally in a volume of 20 ml / kg. Animals are observed after administration for 1 day. Animals receive tap water and standard food to sustain life. Toxicity is determined by the method of Li bchfielel-Wileoxon.
    Antagonism to ptosis due to tetrabenazine in mice.
    Groups of 10 mice each were treated with different doses of the test compound. The control group receives the appropriate amount of carrier orally. After 30 minutes, a dose of 50 mg / kg tetrabenazine was administered intraperitoneally. Animals with ptosis were counted in each group at 20.60.90 and 120 min. Evaluation of the result: the average value of ptosis is calculated on the basis of all measurements in each group, and the deviation from the control group (suppression) is expressed in%. Based on these data, 3DF () values are calculated.
    Antagonism to ptosis due to reserpine in mice.
    Groups of 10 mice each were treated subcutaneously with 6 mg / kg reserpine. The dose of the test compound is administered after 60 minutes. The control group receives only the carrier. Animals with ptosis in each group are counted after 60 and 120 minutes. The results are evaluated and set as in the case of the previous test 2 for ptosis.
    five
    Jq 15
    Jq 25 30
    with up to 45
    50
    its suppression of nicotine-induced seizures.
    Test experience carried out on white | mice by the method of ston. 1 hour after oral administration, 1.4 mg / kg of nicotine was administered intravenously. The resulting convulsions in the treated and control groups are recorded.
    Suppression of convulsions due to pentetrazol.
    The experiment was carried out on white mice according to a modified method of Banziner and Nale. Groups of 6 animals are used for each dose. Due to the administration of 125 mg / kg of pentetrazole intraperitoneally, they cause an extension leg spasm, Oral doses of the test compound are administered 1 hour before the administration of pentetrazole.
    Antiperistaltic effect on mice. Anti-peristaltic action is determined by the Stikkney method and co-workers in white mice (body weight 20-25 g). Doses of the test compound were administered orally 60 minutes before the introduction of the coal suspension. Control animals received, at rare times, a physiological solution of sodium chloride, respectively, another carrier. The animals were sacrificed 20 minutes after the administration of the coal suspension, and the length of the entire small intestine filled with coal was measured. The inhibition, expressed as a percentage of the control, is determined. As a positive action, those cases are considered in which the area filled with coal does not exceed 50% of the entire small intestine. Using transformable data, 3DSO values are calculated,
    i
    Analgesic effect on mice (Writhing test).
    The experiment was carried out on white mice using the modified NeuboulcU method of a 0.75% acetic acid solution administered intraperitoneally in a volume of 20 ml / kg. Suppressions are given expressed in% of the control group.
    The following compounds are tested.
    1) 3- (4-chloro-2-nitrophenyl) -2-iminothiazolidine hydrochloride;
    2) 3- (2-nitro-4-trifluoromethylphenyl) -2-imino-thiazolidine hydrochloride
    3) 3- (5-chloro-2-nitrophenyl) -2-iminothiazolidine;
    91549480
    4) 3- (2-nitrophenyl) -2-iminothiazolidine;
    5) 3- (2-nitro-4-methoxyphenyl) -2- Is iminothiazolidine hydrobromide. With
    The test results are presented in table 1-6.
    Table 1
    10 Table4
    权利要求:
    Claims (1)
    [1]
    Invention Formula
    The method of obtaining iminotisolidine derivatives of the general formula
    (hNNH
    (
    where n is 0 or 1;
    R is halogen, trifluoromethyl or methoxy, or their hydrochlorides, characterized in that. isothiocyanate of the general formula
    SCN
    where R and p have the indicated meanings, cyclize at boiling in a medium of lower aliphatic alcohol in the presence of hydrogen chloride, and the target product is isolated in free form or in the form of its hydrochloride,
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    引用文献:
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